Isoform specific FBXW7 mediates NOTCH1 Abruptex mutation C1133Y deregulation in oral squamous cell carcinoma

Our group previously identified that the NOTCH1 Abruptex domain contains the most mutations in Chinese OSCC patients, including a hotspot mutation (C1133Y). FBXW7 is an E3 ubiquitin ligase that regulates a network of proteins, including NOTCH1, via degradation. In this study, we first described the...

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發表在:Cell Death Dis
Main Authors: Zheng, Yang, Song, An, Wang, Chundi, Zhang, Wei, Liang, Dong, Ding, Xu, Li, Gang, Zhang, Hongchuang, Du, Yifei, Zhou, Junbo, Wu, Heming, Wu, Yunong, Song, Xiaomeng
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426429/
https://ncbi.nlm.nih.gov/pubmed/32792479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02873-4
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