A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma

BACKGROUND: Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies. However, little is known about the biological effect and the clinical...

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Bibliografiske detaljer
Udgivet i:Cancer Cell Int
Main Authors: Zheng, Yang, Wang, Zhao, Ding, Xu, Zhang, Wei, Li, Gang, Liu, Laikui, Wu, Heming, Gu, Wenyi, Wu, Yunong, Song, Xiaomeng
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759178/
https://ncbi.nlm.nih.gov/pubmed/29321718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-017-0496-5
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