A novel Notch1 missense mutation (C1133Y) in the Abruptex domain exhibits enhanced proliferation and invasion in oral squamous cell carcinoma

BACKGROUND: Notch1 has been regarded as a fundamental regulator in tissue differentiation and stem cell properties. Recently, Notch1 mutations have been reported intensively both in solid tumors and in hematopoietic malignancies. However, little is known about the biological effect and the clinical...

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Dettagli Bibliografici
Pubblicato in:Cancer Cell Int
Autori principali: Zheng, Yang, Wang, Zhao, Ding, Xu, Zhang, Wei, Li, Gang, Liu, Laikui, Wu, Heming, Gu, Wenyi, Wu, Yunong, Song, Xiaomeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Primary Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759178/
https://ncbi.nlm.nih.gov/pubmed/29321718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-017-0496-5
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