Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

The mitochondrial calcium uniporter (MCU) is a calcium-activated calcium channel critical for signaling and bioenergetics. MCU, the pore-forming subunit of the uniporter, contains two transmembrane domains and is found in all major eukaryotic taxa. In amoeba and fungi, MCU homologs are sufficient to...

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Vydáno v:Life Sci Alliance
Hlavní autoři: MacEwen, Melissa JS, Markhard, Andrew L, Bozbeyoglu, Mert, Bradford, Forrest, Goldberger, Olga, Mootha, Vamsi K, Sancak, Yasemin
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425227/
https://ncbi.nlm.nih.gov/pubmed/32769116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000718
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