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Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex
The mitochondrial calcium uniporter is a multi-subunit Ca(2+)-activated Ca(2+) channel, made up of the pore-forming MCU protein, a metazoan-specific EMRE subunit, and MICU1/MICU2, which mediate Ca(2+) activation. It has been established that metazoan MCU requires EMRE binding to conduct Ca(2+), but...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7764451/ https://ncbi.nlm.nih.gov/pubmed/33296646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108486 |
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