Radiosynthesis and preclinical evaluation of [(68)Ga]Ga-NOTA-folate for PET imaging of folate receptor β-positive macrophages

Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of [(68)Ga]Ga-NOTA-folate ((68)Ga-FOL). After determining the affinity of (68)Ga-FOL using cells expressing FR-β, we studied a...

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Udgivet i:Sci Rep
Main Authors: Moisio, Olli, Palani, Senthil, Virta, Jenni, Elo, Petri, Liljenbäck, Heidi, Tolvanen, Tuula, Käkelä, Meeri, Miner, Maxwell G., Herre, Erika Atencio, Marjamäki, Päivi, Örd, Tiit, Heinäniemi, Merja, Kaikkonen, Minna U., Zhang, Fenghua, Srinivasarao, Madduri, Knuuti, Juhani, Low, Philip S., Saraste, Antti, Li, Xiang-Guo, Roivainen, Anne
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423886/
https://ncbi.nlm.nih.gov/pubmed/32788595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70394-3
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