Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

Environmental factors are the largest contributors to cardiovascular disease. Here, we show that cardiac organoids incorporating an oxygen-diffusion gradient and stimulated via the neurotransmitter norepinephrine can structurally model the human heart after myocardial infarction (mimicking the gradi...

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Detalhes bibliográficos
Publicado no:Nat Biomed Eng
Main Authors: Richards, Dylan J., Li, Yang, Kerr, Charles M., Yao, Jenny, Beeson, Gyda C., Coyle, Robert C., Chen, Xun, Jia, Jia, Damon, Brooke, Wilson, Robert, Hazard, E. Starr, Hardiman, Gary, Menick, Donald, Beeson, Craig C., Yao, Hai, Ye, Tong, Mei, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422941/
https://ncbi.nlm.nih.gov/pubmed/32284552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-0539-4
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