Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

Damage-associated microglia (DAM) profiles observed in Alzheimer’s disease (AD)-related mouse models reflect an activation state that could modulate AD risk or progression. To learn whether human AD microglia (HAM) display a similar profile, we develop a method for purifying cell types from frozen c...

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Udgivet i:Cell Rep
Main Authors: Srinivasan, Karpagam, Friedman, Brad A., Etxeberria, Ainhoa, Huntley, Melanie A., van der Brug, Marcel P., Foreman, Oded, Paw, Jonathan S., Modrusan, Zora, Beach, Thomas G., Serrano, Geidy E., Hansen, David V.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422733/
https://ncbi.nlm.nih.gov/pubmed/32610143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107843
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