PPARγ Contributes to Immunity Induced by Cancer Cell Vaccines That Secrete GM-CSF

Peroxisome proliferator activated receptor-γ (PPARγ) is a lipid-activated nuclear receptor that promotes immune tolerance through effects on macrophages, dendritic cells (DCs), and regulatory T cells (Tregs). Granulocyte-macrophage colony stimulating factor (GM-CSF) induces PPARγ expression in multi...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Goyal, Girija, Wong, Karrie, Nirschl, Christopher J., Souders, Nicholas, Neuberg, Donna, Anandasabapathy, Niroshana, Dranoff, Glenn
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422646/
https://ncbi.nlm.nih.gov/pubmed/29669721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0612
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