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Programmable inhibition and detection of RNA viruses using Cas13

The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA) viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA). Here, we computationally identify thousands of potential Cas13 crRNA target sites in hundreds of ssRNA viral species that ca...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Freije, Catherine A., Myhrvold, Cameron, Boehm, Chloe K., Lin, Aaron E., Welch, Nicole L., Carter, Amber, Metsky, Hayden C., Luo, Cynthia Y., Abudayyeh, Omar O., Gootenberg, Jonathan S., Yozwiak, Nathan L., Zhang, Feng, Sabeti, Pardis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422627/
https://ncbi.nlm.nih.gov/pubmed/31607545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.013
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