Programmable inhibition and detection of RNA viruses using Cas13

The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA) viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA). Here, we computationally identify thousands of potential Cas13 crRNA target sites in hundreds of ssRNA viral species that ca...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Freije, Catherine A., Myhrvold, Cameron, Boehm, Chloe K., Lin, Aaron E., Welch, Nicole L., Carter, Amber, Metsky, Hayden C., Luo, Cynthia Y., Abudayyeh, Omar O., Gootenberg, Jonathan S., Yozwiak, Nathan L., Zhang, Feng, Sabeti, Pardis C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422627/
https://ncbi.nlm.nih.gov/pubmed/31607545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.013
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