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Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides

Disabled-2 (Dab2) is an adaptor protein that regulates the extent of platelet aggregation by two mechanisms. In the first mechanism, Dab2 intracellularly downregulates the integrin α(IIb)β(3) receptor, converting it to a low affinity state for adhesion and aggregation processes. In the second mechan...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Song, Wei, Gottschalk, Carter J., Tang, Tuo-Xian, Biscardi, Andrew, Ellena, Jeffrey F., Finkielstein, Carla V., Brown, Anne M., Capelluto, Daniel G. S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7421900/
https://ncbi.nlm.nih.gov/pubmed/32782308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70478-0
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