Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif

Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimerize and move laterally across the plasma membrane to phosphatidylinositol (4,5)-bisphosphate-enriched domains. At these sites, TLRs interact with the TIR domain-containing adaptor protein (TIRAP), triggering a signaling casca...

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Publicado en:Sci Rep
Main Authors: Zhao, Xiaolin, Xiong, Wen, Xiao, Shuyan, Tang, Tuo-Xian, Ellena, Jeffrey F., Armstrong, Geoffrey S., Finkielstein, Carla V., Capelluto, Daniel G. S.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320522/
https://ncbi.nlm.nih.gov/pubmed/28225045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43043
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