Antianemia Drug Roxadustat (FG-4592) Protects Against Doxorubicin-Induced Cardiotoxicity by Targeting Antiapoptotic and Antioxidative Pathways

Doxorubicin (DOX) is broadly used in treating various malignant tumors. However, its cardiotoxicity limits its clinical use. Roxadustat (FG-4592) is a new hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor and has been approved for treating anemia in chronic kidney diseases (CKD) patien...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Long, Guangfeng, Chen, Hongbing, Wu, Mengying, Li, Yuanyuan, Gao, Ling, Huang, Songming, Zhang, Yue, Jia, Zhanjun, Xia, Weiwei
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7419679/
https://ncbi.nlm.nih.gov/pubmed/32848792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01191
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