Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging

Endothelial dysfunction (EnD) occurs with aging and endothelial nitric oxide (NO) production by NO synthase (NOS) can be impaired. Low NO levels have been linked to increased arginase (Ar) activity as Ar competes with NOS for L-arginine. The inhibition of Ar activity can reverse EnD and (−)-epicatec...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Garate-Carrillo, Alejandra, Navarrete-Yañez, Viridiana, Ortiz-Vilchis, Pilar, Guevara, Gustavo, Castillo, Carmen, Mendoza-Lorenzo, Patricia, Ceballos, Guillermo, Ortiz-Flores, Miguel, Najera, Nayelli, Bustamante-Pozo, Moises Muratt, Rubio-Gayosso, Ivan, Villarreal, Francisco, Ramirez-Sanchez, Israel
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2020
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Full Length Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418791/
https://ncbi.nlm.nih.gov/pubmed/32795514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2020.173442
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