Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging

Endothelial dysfunction (EnD) occurs with aging and endothelial nitric oxide (NO) production by NO synthase (NOS) can be impaired. Low NO levels have been linked to increased arginase (Ar) activity as Ar competes with NOS for L-arginine. The inhibition of Ar activity can reverse EnD and (−)-epicatec...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Eur J Pharmacol
Autori principali: Garate-Carrillo, Alejandra, Navarrete-Yañez, Viridiana, Ortiz-Vilchis, Pilar, Guevara, Gustavo, Castillo, Carmen, Mendoza-Lorenzo, Patricia, Ceballos, Guillermo, Ortiz-Flores, Miguel, Najera, Nayelli, Bustamante-Pozo, Moises Muratt, Rubio-Gayosso, Ivan, Villarreal, Francisco, Ramirez-Sanchez, Israel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier B.V. 2020
Soggetti:
Full Length Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418791/
https://ncbi.nlm.nih.gov/pubmed/32795514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2020.173442
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