BRCA1 mutational complementation induces synthetic viability

BRCA1 promotes the DNA end-resection and RAD51 loading steps of homologous recombination (HR). Whether these functions can be uncoupled, or if mutant proteins retaining partial activity can complement one another, is unclear, and could impact the severity of BRCA1-associated Fanconi anemia (FA). Her...

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Publicat a:Mol Cell
Autors principals: Nacson, Joseph, Marcantonio, Daniela Di, Wang, Yifan, Bernhardy, Andrea J., Clausen, Emma, Hua, Xiang, Cai, Kathy Q., Martinez, Esteban, Feng, Wanjuan, Callén, Elsa, Wu, Wei, Gupta, Gaorav P., Testa, Joseph R., Nussenzweig, André, Sykes, Stephen M., Johnson, Neil
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418109/
https://ncbi.nlm.nih.gov/pubmed/32359443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.04.006
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