BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

BRCA1 functions in homologous recombination (HR) both up- and downstream of DNA end resection. However, in cells with 53BP1 gene knockout (KO), BRCA1 is dispensable for the initiation of resection, but whether BRCA1 activity is entirely redundant after end resection is unclear. Here, we found that 5...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Nacson, Joseph, Krais, John J., Bernhardy, Andrea J., Clausen, Emma, Feng, Wanjuan, Wang, Yifan, Nicolas, Emmanuelle, Cai, Kathy Q., Tricarico, Rossella, Hua, Xiang, DiMarcantonio, Daniela, Martinez, Esteban, Zong, Dali, Handorf, Elizabeth A., Bellacosa, Alfonso, Testa, Joseph R., Nussenzweig, Andre, Gupta, Gaorav P., Sykes, Stephen M., Johnson, Neil
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219632/
https://ncbi.nlm.nih.gov/pubmed/30257212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.086
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