BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

BRCA1 functions in homologous recombination (HR) both up- and downstream of DNA end resection. However, in cells with 53BP1 gene knockout (KO), BRCA1 is dispensable for the initiation of resection, but whether BRCA1 activity is entirely redundant after end resection is unclear. Here, we found that 5...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Nacson, Joseph, Krais, John J., Bernhardy, Andrea J., Clausen, Emma, Feng, Wanjuan, Wang, Yifan, Nicolas, Emmanuelle, Cai, Kathy Q., Tricarico, Rossella, Hua, Xiang, DiMarcantonio, Daniela, Martinez, Esteban, Zong, Dali, Handorf, Elizabeth A., Bellacosa, Alfonso, Testa, Joseph R., Nussenzweig, Andre, Gupta, Gaorav P., Sykes, Stephen M., Johnson, Neil
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219632/
https://ncbi.nlm.nih.gov/pubmed/30257212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.086
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