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Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis

Osteoarthritis (OA) affects nearly 10% of the population of the United States and other industrialized countries and, at present, short of surgical joint replacement, there is no therapy available that can reverse the progression of the disease. Adenosine, acting at its A2A receptor (A2AR), is a cri...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Corciulo, Carmen, Castro, Cristina M., Coughlin, Thomas, Jacob, Samson, Li, Zhu, Fenyö, David, Rifkin, Daniel B., Kennedy, Oran D., Cronstein, Bruce Neil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418027/
https://ncbi.nlm.nih.gov/pubmed/32778777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68302-w
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