Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

Osteoarthritis (OA) is characterized by cartilage destruction and chondrocytes have a central role in this process. With age and inflammation chondrocytes have reduced capacity to synthesize and maintain ATP, a molecule important for cartilage homeostasis. Here we show that concentrations of ATP and...

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Pubblicato in:Nat Commun
Autori principali: Corciulo, Carmen, Lendhey, Matin, Wilder, Tuere, Schoen, Hanna, Cornelissen, Alexander Samuel, Chang, Gregory, Kennedy, Oran D., Cronstein, Bruce N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437286/
https://ncbi.nlm.nih.gov/pubmed/28492224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15019
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