Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

INTRODUCTION: Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait c...

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Autors principals: Plaas, Anna, Li, Jun, Riesco, Julie, Das, Rosalina, Sandy, John D, Harrison, Andrew
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3132032/
https://ncbi.nlm.nih.gov/pubmed/21418601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3286
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