Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3

BACKGROUND: Long QT syndrome 3 (LQT3) is caused by SCN5A mutations. Late sodium current (late I (Na)) inhibitors are current-specific to treat patients with LQT3, but the mechanisms underlying mexiletine (MEX) -sensitive (N1325S and R1623Q) and -insensitive (M1652R) mutations remains to be elucidate...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Li, Gang, Woltz, Ryan L., Wang, Cheng-yu, Ren, Lu, He, Pei-xin, Yu, Shan-dong, Liu, Xue-qin, Yarov-Yarovoy, Vladimir, Hu, Dan, Chiamvimonvat, Nipavan, Wu, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7417866/
https://ncbi.nlm.nih.gov/pubmed/32848785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01182
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