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Radiotherapy cooperates with IL15 to induce antitumor immune responses

Focal radiotherapy can promote cross-presentation of tumor antigens to T cells, but by itself it is insufficient to induce therapeutically effective T-cell responses. The common gamma-chain cytokine IL15 promotes and sustains the proliferation and effector function of CD8(+) T cells, but has limited...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Pilones, Karsten A., Charpentier, Maud, Garcia-Martinez, Elena, Daviaud, Camille, Kraynak, Jeffrey, Aryankalayil, Joseph, Formenti, Silvia C., Demaria, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415682/
https://ncbi.nlm.nih.gov/pubmed/32532811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0338
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