Role of nanoscale antigen organization on B-cell activation probed using DNA origami

Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance B cell activation. However, the effects of antigen copy number, spacing, and affinity, as well as the dimensionality and rigidity of scaffold presentation on B cell activation remain p...

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Detaylı Bibliyografya
Yayımlandı:Nat Nanotechnol
Asıl Yazarlar: Veneziano, Rémi, Moyer, Tyson J., Stone, Matthew B., Wamhoff, Eike-Christian, Read, Benjamin J., Mukherjee, Sayak, Shepherd, Tyson R., Das, Jayajit, Schief, William R., Irvine, Darrell J., Bathe, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415668/
https://ncbi.nlm.nih.gov/pubmed/32601450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41565-020-0719-0
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