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Enhanced expression of catalase in mitochondria modulates NF-κB dependent lung inflammation through alteration of metabolic activity in macrophages

NF-κB is a redox sensitive transcription factor that plays a key role in regulating the immune response. In these studies, we intended to investigate the role of mitochondrial-derived reactive oxygen species (ROS) in regulating NF-κB activation by studying transgenic mice that over-express mitochond...

詳細記述

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書誌詳細
出版年:J Immunol
主要な著者: Han, Wei, Fessel, Joshua P., Sherrill, Taylor, Kocurek, Emily G., Yull, Fiona E., Blackwell, Timothy S.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415609/
https://ncbi.nlm.nih.gov/pubmed/32601098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900820
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