Identification of a RAS-activating TMEM87A-RASGRF1 fusion in an exceptional responder to sunitinib with non-small cell lung cancer

PURPOSE: We pursued genomic analysis of an exceptional responder with non-small cell lung cancer (NSCLC) through a multi-platform effort to discover novel oncogenic targets. METHODS: In this open-label, single-arm phase II study (NCT01829217), an enriched cohort of patients with advanced NSCLC were...

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Pubblicato in:Clin Cancer Res
Autori principali: Cooper, Alissa J, Kobayashi, Yoshihisa, Kim, Dewey, Clifford, Sarah E, Kravets, Sasha, Dahlberg, Suzanne E, Chambers, Emily S, Li, Jiaqi, Rangachari, Deepa, Nguyen, Tom, Costa, Daniel B, Rabin, Michael S, Wagle, Nikhil, Sholl, Lynette M, Jänne, Pasi A, Oxnard, Geoffrey R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415568/
https://ncbi.nlm.nih.gov/pubmed/32312893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-0397
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