Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

PURPOSE: Rare genetic variants in complement factor I (CFI) that cause low systemic levels of the protein (FI) have been reported as a strong risk factor for advanced age-related macular degeneration (AMD). This study set out to replicate these findings. METHODS: FI levels were measured by sandwich...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Hallam, Thomas M., Marchbank, Kevin J., Harris, Claire L., Osmond, Clive, Shuttleworth, Victoria G., Griffiths, Helen, Cree, Angela J., Kavanagh, David, Lotery, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415286/
https://ncbi.nlm.nih.gov/pubmed/32516404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.6.18
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