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Heme induces rapid endothelial barrier dysfunction via the MKK3/p38MAPK axis

Several studies demonstrate that hemolysis and free heme in circulation cause endothelial barrier dysfunction and are associated with severe pathological conditions such as acute respiratory distress syndrome, acute chest syndrome, and sepsis. However, the precise molecular mechanisms involved in th...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: James, Joel, Srivastava, Anup, Varghese, Mathews Valuparampil, Eccles, Cody A., Zemskova, Marina, Rafikova, Olga, Rafikov, Ruslan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414589/
https://ncbi.nlm.nih.gov/pubmed/32548640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003986
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