Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells

Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic H1N1 viruses. The same dominant PB2 mutation is also found in most human isolates of emergent av...

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Detaylı Bibliyografya
Yayımlandı:J Gen Virol
Asıl Yazarlar: Gao, Weihua, Zu, Zhipeng, Liu, Jiyu, Song, Jingwei, Wang, Xinyu, Wang, Chenxi, Liu, Litao, Tong, Qi, Wang, Mingyang, Sun, Honglei, Sun, Yipeng, Liu, Jinhua, Chang, Kin-Chow, Pu, Juan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Microbiology Society 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414430/
https://ncbi.nlm.nih.gov/pubmed/31305236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001294
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