Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity

Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that PA mutation K356R (PA-K356R) has become predominant since 2014 in avian H9N2 viruses in China as with seasonal human H1N1 viruses. The sa...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Xu, Guanlong, Zhang, Xuxiao, Gao, Weihua, Wang, Chenxi, Wang, Jinliang, Sun, Honglei, Sun, Yipeng, Guo, Lu, Zhang, Rui, Chang, Kin-Chow, Liu, Jinhua, Pu, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008101/
https://ncbi.nlm.nih.gov/pubmed/27384648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00883-16
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