An R195K Mutation in the PA-X Protein Increases the Virulence and Transmission of Influenza A Virus in Mammalian Hosts

In the 21st century, the emergence of H7N9 and H1N1/2009 influenza viruses, originating from animals and causing severe human infections, has prompted investigations into the genetic alterations required for cross-species transmission. We previously found that replacement of the human-origin PA gene...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Sun, Yipeng, Hu, Zhe, Zhang, Xuxiao, Chen, Mingyue, Wang, Zhen, Xu, Guanlong, Bi, Yuhai, Tong, Qi, Wang, Mingyang, Sun, Honglei, Pu, Juan, Iqbal, Munir, Liu, Jinhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269435/
https://ncbi.nlm.nih.gov/pubmed/32161172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01817-19
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