Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells

Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic H1N1 viruses. The same dominant PB2 mutation is also found in most human isolates of emergent av...

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Bibliographic Details
Published in:J Gen Virol
Main Authors: Gao, Weihua, Zu, Zhipeng, Liu, Jiyu, Song, Jingwei, Wang, Xinyu, Wang, Chenxi, Liu, Litao, Tong, Qi, Wang, Mingyang, Sun, Honglei, Sun, Yipeng, Liu, Jinhua, Chang, Kin-Chow, Pu, Juan
Format: Artigo
Language:Inglês
Published: Microbiology Society 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414430/
https://ncbi.nlm.nih.gov/pubmed/31305236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001294
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