An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yao, Yao, Kadam, Rameshwar U., Lee, Chang-Chun David, Woehl, Jordan L., Wu, Nicholas C., Zhu, Xueyong, Kitamura, Seiya, Wilson, Ian A., Wolan, Dennis W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414093/
https://ncbi.nlm.nih.gov/pubmed/32690700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006893117
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