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Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin
Influenza is a highly contagious respiratory viral infection responsible for up to 50,000 deaths per annum in the US alone. The need for new therapeutics with novel modes of action is of paramount importance. We determined the x-ray structure of Arbidol with influenza hemagglutinin and found it was...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5575851/ https://ncbi.nlm.nih.gov/pubmed/28689973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.06.074 |
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