Notch and TLR signaling coordinate monocyte cell fate and inflammation

Conventional Ly6C(hi) monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6C(hi) monocytes, and...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gamrekelashvili, Jaba, Kapanadze, Tamar, Sablotny, Stefan, Ratiu, Corina, Dastagir, Khaled, Lochner, Matthias, Karbach, Susanne, Wenzel, Philip, Sitnow, Andre, Fleig, Susanne, Sparwasser, Tim, Kalinke, Ulrich, Holzmann, Bernhard, Haller, Hermann, Limbourg, Florian P
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413669/
https://ncbi.nlm.nih.gov/pubmed/32723480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57007
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