Regulation of monocyte cell fate by blood vessels mediated by Notch signalling

A population of monocytes, known as Ly6C(lo) monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments...

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Pubblicato in:Nat Commun
Autori principali: Gamrekelashvili, Jaba, Giagnorio, Roberto, Jussofie, Jasmin, Soehnlein, Oliver, Duchene, Johan, Briseño, Carlos G., Ramasamy, Saravana K., Krishnasamy, Kashyap, Limbourg, Anne, Häger, Christine, Kapanadze, Tamar, Ishifune, Chieko, Hinkel, Rabea, Radtke, Freddy, Strobl, Lothar J., Zimber-Strobl, Ursula, Napp, L. Christian, Bauersachs, Johann, Haller, Hermann, Yasutomo, Koji, Kupatt, Christian, Murphy, Kenneth M., Adams, Ralf H., Weber, Christian, Limbourg, Florian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013671/
https://ncbi.nlm.nih.gov/pubmed/27576369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12597
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