Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions

Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ~2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders. Targeting microsatellites with dedicated DNA endonucleases could become a...

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Vydáno v:PLoS Genet
Hlavní autoři: Mosbach, Valentine, Viterbo, David, Descorps-Declère, Stéphane, Poggi, Lucie, Vaysse-Zinkhöfer, Wilhelm, Richard, Guy-Franck
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413560/
https://ncbi.nlm.nih.gov/pubmed/32673314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008924
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