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Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
Trinucleotide repeat expansions are responsible for more than two dozens severe neurological disorders in humans. A double-strand break between two short CAG/CTG trinucleotide repeats was formerly shown to induce a high frequency of repeat contractions in yeast. Here, using a dedicated TALEN, we sho...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3991675/ https://ncbi.nlm.nih.gov/pubmed/24748175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095611 |
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