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Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

The aims of the present study were to investigate the role of sphingosine kinase 2 (Sphk2) in hypertrophic scar (HS) formation and its underlying mechanisms. The expression levels of Sphk2 and Smad7 in HS tissues and healthy skin tissues of patients undergoing plastic surgery were determined using i...

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Détails bibliographiques
Publié dans:Mol Med Rep
Auteurs principaux: Zeng, Jian, Jiang, Bin, Xiao, Xia, Zhang, Rou
Format: Artigo
Langue:Inglês
Publié: D.A. Spandidos 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411334/
https://ncbi.nlm.nih.gov/pubmed/32705254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11313
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