Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts

The aims of the present study were to investigate the role of sphingosine kinase 2 (Sphk2) in hypertrophic scar (HS) formation and its underlying mechanisms. The expression levels of Sphk2 and Smad7 in HS tissues and healthy skin tissues of patients undergoing plastic surgery were determined using i...

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Bibliographic Details
Published in:Mol Med Rep
Main Authors: Zeng, Jian, Jiang, Bin, Xiao, Xia, Zhang, Rou
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2020
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411334/
https://ncbi.nlm.nih.gov/pubmed/32705254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11313
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