Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells

Fatty acid synthase, a key enzyme of de novo lipogenesis, is an attractive therapeutic target in cancer. The novel fatty acid synthase inhibitor, TVB-3664, shows anti-cancer activity in multiple cancers including colorectal cancer; however, it is unclear whether uptake of exogeneous fatty acids can...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Drury, James, Rychahou, Piotr G., He, Daheng, Jafari, Naser, Wang, Chi, Lee, Eun Y., Weiss, Heidi L., Evers, Bernard Mark, Zaytseva, Yekaterina Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411002/
https://ncbi.nlm.nih.gov/pubmed/32850342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01185
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