Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer

Fatty Acid Synthase (FASN) and ATP-citrate lyase (ACLY), key enzymes of de novo lipogenesis, are significantly upregulated and activated in many cancers and portend poor prognosis. Even though the role of lipogenesis in providing proliferative and survival advantages to cancer cells has been describ...

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Main Authors: Zaytseva, Yekaterina Y., Rychahou, Piotr G., Gulhati, Pat, Elliott, Victoria A., Mustain, William C., O’Connor, Kathleen, Morris, Andrew J., Sunkara, Manjula, Weiss, Heidi L., Lee, Eun Y., Evers, B. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596828/
https://ncbi.nlm.nih.gov/pubmed/22266115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-4057
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