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Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax

Clinical failure of primaquine (PQ) has been demonstrated in people with CYP450 2D6 genetic polymorphisms that result in reduced or no enzyme activity. The distribution of CYP2D6 genotypes and predicted phenotypes in the Cambodian population is not well described. Surveys in other Asian countries ha...

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Pubblicato in:Am J Trop Med Hyg
Autori principali: Spring, Michele D., Lon, Chanthap, Sok, Somethy, Sea, Darapiseth, Wojnarski, Mariusz, Chann, Soklyda, Kuntawunginn, Worachet, Kheang Heng, Thay, Nou, Samon, Arsanok, Montri, Sriwichai, Sabaithip, Vanachayangkul, Pattaraporn, Lin, Jessica T., Manning, Jessica E., Jongsakul, Krisada, Pichyangkul, Sathit, Satharath, Prom, Smith, Philip L., Dysoley, Lek, Saunders, David L., Waters, Norman C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Tropical Medicine and Hygiene 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410472/
https://ncbi.nlm.nih.gov/pubmed/32394887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.20-0061
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