Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency

Aging is associated with a high prevalence of hypertension due to elevated susceptibility of BP to dietary salt, but its mechanism is unknown. Serum levels of Klotho, an anti-aging factor, decline with age. We found that high salt (HS) increased BP in aged mice and young heterozygous Klotho-knockout...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kawarazaki, Wakako, Mizuno, Risuke, Nishimoto, Mitsuhiro, Ayuzawa, Nobuhiro, Hirohama, Daigoro, Ueda, Kohei, Kawakami-Mori, Fumiko, Oba, Shigeyoshi, Marumo, Takeshi, Fujita, Toshiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410076/
https://ncbi.nlm.nih.gov/pubmed/32597829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI134431
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