Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity

Fibrinolysis is initiated by tissue-type plasminogen activator (tPA) and inhibited by plasminogen activator inhibitor 1 (PAI-1). In obese humans, plasma PAI-1 and tPA proteins are increased, but PAI-1 dominates, leading to reduced fibrinolysis and thrombosis. To understand tPA–PAI-1 regulation in ob...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zheng, Ze, Nakamura, Keiko, Gershbaum, Shana, Wang, Xiaobo, Thomas, Sherry, Bessler, Marc, Schrope, Beth, Krikhely, Abraham, Liu, Rui-Ming, Ozcan, Lale, López, José A., Tabas, Ira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410057/
https://ncbi.nlm.nih.gov/pubmed/32657780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135919
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