Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action

There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the p53 and MDM2 pathways in human glioma, which play critical roles in drug resistance. The present study was designed to evaluate the in vitro and...

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Udgivet i:Cells
Main Authors: Punganuru, Surendra R., Arutla, Viswanath, Zhao, Wei, Rajaei, Mehrdad, Deokar, Hemantkumar, Zhang, Ruiwen, Buolamwini, John K., Srivenugopal, Kalkunte S., Wang, Wei
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408354/
https://ncbi.nlm.nih.gov/pubmed/32630235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071592
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