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Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action

There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the p53 and MDM2 pathways in human glioma, which play critical roles in drug resistance. The present study was designed to evaluate the in vitro and...

詳細記述

保存先:
書誌詳細
出版年:Cells
主要な著者: Punganuru, Surendra R., Arutla, Viswanath, Zhao, Wei, Rajaei, Mehrdad, Deokar, Hemantkumar, Zhang, Ruiwen, Buolamwini, John K., Srivenugopal, Kalkunte S., Wang, Wei
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408354/
https://ncbi.nlm.nih.gov/pubmed/32630235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071592
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