Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process. There are no reports in the literature...

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Vydáno v:Pharmaceutics
Hlavní autoři: H. Aodah, Alhussain, H. Fayed, Mohamed, Alalaiwe, Ahmed, B. Alsulays, Bader, F. Aldawsari, Mohammed, Khafagy, El-Sayed
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408287/
https://ncbi.nlm.nih.gov/pubmed/32605039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12070598
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