Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique

Sildenafil citrate undergoes first-pass metabolism, resulting in poor oral bioavailability at 25–41% of the administered dose. This study aimed to design and optimize fast-disintegrating tablets for the sublingual delivery of sildenafil citrate to improve bioavailability and facilitate rapid onset o...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: AlAli, Amer S., Aldawsari, Mohammed F., Alalaiwe, Ahmed, Almutairy, Bjad K., Al-Shdefat, Ramadan, Walbi, Ismail A., Fayed, Mohamed H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231530/
https://ncbi.nlm.nih.gov/pubmed/34204781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060870
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