Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach

Compression of cohesive, poorly compactable, and high-dose metformin hydrochloride into the orally disintegrating tablet (ODT) is challenging. The objective of this study was to develop metformin ODT using the moisture activated dry granulation (MADG) process. There are no reports in the literature...

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Publicado en:Pharmaceutics
Main Authors: H. Aodah, Alhussain, H. Fayed, Mohamed, Alalaiwe, Ahmed, B. Alsulays, Bader, F. Aldawsari, Mohammed, Khafagy, El-Sayed
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408287/
https://ncbi.nlm.nih.gov/pubmed/32605039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12070598
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